Director, Protein Engineering & Expression
CSLCity of Melbourne, Victoria, Australia8 days ago
Job descriptionProvide strategic direction for research projects, ensuring alignment with overall company goals and objectives. Gene‑of‑interest and expression vector optimization, and small to large‑scale recombinant protein generation and characterization. Lead projects on protein engineering and optimization. Develop strategies to overcome technical challenges. Design and optimize therapeutic proteins using rational and computational protein engineering approaches to enhance potency, stability, solubility, and reduce immunogenicity. Serve as the protein engineering lead on cross‑functional teams, aligning strategies with discovery and development goals. Ensure the timely progression of projects from concept through to clinical development, adhering to high scientific and regulatory standards. Identify and evaluate emerging trends and technologies to maintain a competitive edge. Support internal research activities and manage external projects, including performing internal wet lab due diligence activities, ensuring necessary resources and expertise. Support research and lifecycle management activities across CSL’s therapeutic areas of interest. Optimize project milestones, budgets, and resource allocation. Provide technical reports and advice to senior management. Recognized subject matter expert in the job area typically obtained through advanced education and work experience. Provide guidance and mentorship to the Protein Engineering and Expression team. Ensure best practices in experimental design, data analysis, and compliance with legislation. Communicate scientific results clearly and concisely to appropriate audiences. Support intellectual property filings with technical descriptions. Identify and foster partnerships with cross‑functional CSL R&D teams, academic institutions, industry experts, and collaborators to ensure timely project progression. Represent the organization at scientific conferences and industry meetings. Drive innovation by integrating novel technologies and approaches. Stay current with emerging technologies to enhance the drug discovery process and support lifecycle management. Postgraduate degree (preferably PhD) in Molecular Biology, Protein Biochemistry, and / or extensive experience in relevant industry or academic environment. A minimum of 10 years of experience, with a proven track record of successful research and development projects. Prior experience in a leadership role is essential. Significant experience with generative AI, including hands‑on experience using state‑of‑the‑art machine learning tools such as AlphaFold, RFdiffusion, ProteinMPNN or similar models. Ability to build and train machine learning models highly regarded. Significant experience in recombinant protein expression and characterization using state‑of‑the‑art transient and stable expression platforms. Experience with high‑throughput technologies and automation platforms highly regarded. Strong leadership and management skills, with the ability to inspire and motivate a team of researchers. Excellent strategic thinking and problem‑solving abilities. Outstanding written and verbal communication skills, with the ability to present complex scientific concepts to diverse audiences. Strong networking skills.
CSL's R&D organization is accelerating innovation to deliver greater impact for patients. With a project‑led structure and a focus on collaboration, we’re building a future‑ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.
Your Opportunity
This role will lead a team and provide high level expertise and leadership capacity in the specialist areas of protein engineering and recombinant protein expression in support of pipeline drug discovery. Requires a strategic vision, scientific expertise with multiple therapeutic protein modalities across Research and Development, proven experience working with and managing external academic and industry partners, and leadership skills to drive innovation and ensure the successful discovery and progression of drug candidates.
Your Responsibilities Will Include
Leadership and Strategy
- Responsible for leadership and development of research employees, fostering innovation and excellence.
- Develop and implement a strategic vision for cutting edge protein engineering capabilities that supports CSL’s therapeutic antibody and recombinant protein drug discovery efforts.
Research and Development
Project Management
Scientific Oversight
Collaboration and Networking
Innovation and Technology
Your Skills & Experience
Our Benefits
We encourage you to make your well‑being a priority. It’s important and so are you. Learn more about how we care at CSL.
About CSL
CSL is a leading global biotechnology company with a dynamic portfolio of life‑saving medicines, including those that treat haemophilia and immune deficiencies, as well as vaccines to prevent influenza. Since our start in 1916, we have been driven by our promise to save lives through innovation. Learn more about CSL.
We want CSL to reflect the world around us
At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future. Learn more Inclusion and Belonging | CSL.
Do work that matters at CSL!
Seniority level
Not Applicable
Employment type
Full‑time
Job function
Engineering and Information Technology
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Director Engineering • City of Melbourne, Victoria, Australia
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