Senior Director, Genomics & Bioinformatics

Overview

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR / Cas12a and CRISPR / Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases.

At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor!

Decoding The Role

Editas is seeking a Senior Director of Genomics and Bioinformatics to be a pivotal scientific and strategic leader within our Research & Translational Organization. The individual will provide leadership for the assessment and implementation of advanced genomics and analytical methods crucial for target discovery and for the design and execution of in-silico and experimental strategies that guide our programs from discovery through clinical development. This role will be responsible for the company's strategy for off-target nomination and analysis, a critical component of developing safe and effective CRISPR-based medicines. You will lead a talented team of scientists performing human statistical genetics, computational biology, NGS, in vitro screening, and bioinformatics. As our subject matter expert, you will be responsible for articulating our off-target analysis strategy and data packages to global regulatory agencies. This is a highly cross-functional role that requires a strong partner to our Discovery Research, Nonclinical, Clinical, and Regulatory teams to drive our therapeutic programs forward.

Characterizing Your Impact

As the Senior Director of Genomics / Informatics, you will :

• Develop and lead the overarching strategy for off-target nomination and assessment for all therapeutic programs, ensuring cutting-edge, phase-appropriate, and rigorous approaches.
• Serve as the subject matter expert on off-target analysis for global regulatory submissions (IND, BLA) and agency interactions, clearly and convincingly communicating our strategy and findings.
• Lead, mentor, and grow a high-performing team of scientists performing NGS, in vitro screening, statistical genetics, and computational biologists and bioinformaticians, fostering a culture of innovation, scientific excellence, and collaboration.
• Oversee the design, execution, and analysis of large-scale Next-Generation Sequencing (NGS) datasets to identify and characterize potential on- and off-target editing events.
• Drive the evaluation and implementation of novel computational tools, algorithms, and machine learning models to continuously improve the precision and efficiency of our genomic analyses.
• Partner closely with discovery, nonclinical, regulatory and clinical teams to integrate genomic insights, guide experimental design, and inform program decisions.
• Author and review relevant sections of regulatory documents and scientific publications, ensuring clarity, accuracy, and strategic alignment.

The Ideal Transcript

To thrive in this role, you’ll need :

Fundamentals That Set You Apart

Benefits and Compensation

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

Salary Range : $270,000 - $290,000

Pay Transparency

Editas Medicine is committed to transparency and accuracy in our hiring practices. The anticipated salary range for each position is posted within the role. The final salary offer will be determined based on a comprehensive assessment of the candidate's qualifications, including education, training, and relevant experience. Additional factors such as external market conditions, the role's criticality, and internal equity will also be considered. Editas Medicine's compensation philosophy ensures fair and equitable pay practices.

Aspire to be an Editor? We invite you to apply and join us at the forefront of innovation and be a key contributor to realizing Editas Medicine's mission of developing transformative medicines for people living with serious diseases.

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